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Inactivation of interferon receptor promotes the establishment of immune privileged tumor microenvironment

Refractoriness of solid tumors including colorectal cancers (CRC) to immunotherapies is attributed to the immunosuppressive tumor microenvironment that protects malignant cells from cytotoxic T lymphocytes (CTL). We found that downregulation of the type I interferon receptor chain IFNAR1 occurs in h...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Katlinski, Kanstantsin V., Gui, Jun, Katlinskaya, Yuliya V., Ortiz, Angelíca, Chakraborty, Riddhita, Bhattacharya, Sabyasachi, Carbone, Christopher J., Beiting, Daniel P., Girondo, Melanie A., Peck, Amy R., Puré, Ellen, Chatterji, Priya, Rustgi, Anil K., Diehl, J. Alan, Koumenis, Constantinos, Rui, Hallgeir, Fuchs, Serge Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313042/
https://ncbi.nlm.nih.gov/pubmed/28196594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.01.004
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