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Inactivation of interferon receptor promotes the establishment of immune privileged tumor microenvironment

Refractoriness of solid tumors including colorectal cancers (CRC) to immunotherapies is attributed to the immunosuppressive tumor microenvironment that protects malignant cells from cytotoxic T lymphocytes (CTL). We found that downregulation of the type I interferon receptor chain IFNAR1 occurs in h...

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Bibliografski detalji
Izdano u:Cancer Cell
Glavni autori: Katlinski, Kanstantsin V., Gui, Jun, Katlinskaya, Yuliya V., Ortiz, Angelíca, Chakraborty, Riddhita, Bhattacharya, Sabyasachi, Carbone, Christopher J., Beiting, Daniel P., Girondo, Melanie A., Peck, Amy R., Puré, Ellen, Chatterji, Priya, Rustgi, Anil K., Diehl, J. Alan, Koumenis, Constantinos, Rui, Hallgeir, Fuchs, Serge Y.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313042/
https://ncbi.nlm.nih.gov/pubmed/28196594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.01.004
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