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The external domains of the HIV-1 envelope are a mutational cold spot

In RNA viruses, mutations occur fast and have large fitness effects. While this affords remarkable adaptability, it can also endanger viral survival due to the accumulation of deleterious mutations. How RNA viruses reconcile these two opposed facets of mutation is still unknown. Here we show that, i...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Geller, Ron, Domingo-Calap, Pilar, Cuevas, José M., Rossolillo, Paola, Negroni, Matteo, Sanjuán, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687473/
https://ncbi.nlm.nih.gov/pubmed/26450412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9571
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