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The external domains of the HIV-1 envelope are a mutational cold spot

In RNA viruses, mutations occur fast and have large fitness effects. While this affords remarkable adaptability, it can also endanger viral survival due to the accumulation of deleterious mutations. How RNA viruses reconcile these two opposed facets of mutation is still unknown. Here we show that, i...

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Publicat a:Nat Commun
Autors principals: Geller, Ron, Domingo-Calap, Pilar, Cuevas, José M., Rossolillo, Paola, Negroni, Matteo, Sanjuán, Rafael
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687473/
https://ncbi.nlm.nih.gov/pubmed/26450412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9571
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