Dual Specificity Phosphatase 5, a Specific Negative Regulator of ERK Signaling, Is Induced by Serum Response Factor and Elk-1 Transcription Factor

Serum stimulation of mammalian cells induces, via the MAPK pathway, the nuclear protein DUSP5 (dual-specificity phosphatase 5), which specifically interacts with and inactivates the ERK1/2 MAP kinases. However, molecular mechanisms underlying DUSP5 induction are not well known. Here, we found that t...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Buffet, Camille, Catelli, Maria-Grazia, Hecale-Perlemoine, Karine, Bricaire, Léopoldine, Garcia, Camille, Gallet-Dierick, Anne, Rodriguez, Stéphanie, Cormier, Françoise, Groussin, Lionel
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687125/
https://ncbi.nlm.nih.gov/pubmed/26691724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145484
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