DUSP5 and DUSP6, two ERK specific phosphatases, are markers of a higher MAPK signaling activation in BRAF mutated thyroid cancers

BACKGROUND: Molecular alterations of the MAPK pathway are frequently observed in papillary thyroid carcinomas (PTCs). It leads to a constitutive activation of the signalling pathway through an increase in MEK and ERK phosphorylation. ERK is negatively feedback-regulated by Dual Specificity Phosphata...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Buffet, Camille, Hecale-Perlemoine, Karine, Bricaire, Léopoldine, Dumont, Florent, Baudry, Camille, Tissier, Frédérique, Bertherat, Jérôme, Cochand-Priollet, Beatrix, Raffin-Sanson, Marie-Laure, Cormier, Françoise, Groussin, Lionel
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599027/
https://ncbi.nlm.nih.gov/pubmed/28910386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184861
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