Differential Toll-Like Receptor-Signalling of Burkholderia pseudomallei Lipopolysaccharide in Murine and Human Models

The Gram-negative bacterium Burkholderia pseudomallei causes melioidosis and is a CDC category B bioterrorism agent. Toll-like receptor (TLR)-2 impairs host defense during pulmonary B.pseudomallei infection while TLR4 only has limited impact. We investigated the role of TLRs in B.pseudomallei-lipopo...

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Publicado en:PLoS One
Autores principales: Weehuizen, Tassili A. F., Prior, Joann L., van der Vaart, Thomas W., Ngugi, Sarah A., Nepogodiev, Sergey A., Field, Robert A., Kager, Liesbeth M., van ‘t Veer, Cornelis, de Vos, Alex F., Wiersinga, W. Joost
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687033/
https://ncbi.nlm.nih.gov/pubmed/26689559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145397
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