Differential Toll-Like Receptor-Signalling of Burkholderia pseudomallei Lipopolysaccharide in Murine and Human Models

The Gram-negative bacterium Burkholderia pseudomallei causes melioidosis and is a CDC category B bioterrorism agent. Toll-like receptor (TLR)-2 impairs host defense during pulmonary B.pseudomallei infection while TLR4 only has limited impact. We investigated the role of TLRs in B.pseudomallei-lipopo...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Weehuizen, Tassili A. F., Prior, Joann L., van der Vaart, Thomas W., Ngugi, Sarah A., Nepogodiev, Sergey A., Field, Robert A., Kager, Liesbeth M., van ‘t Veer, Cornelis, de Vos, Alex F., Wiersinga, W. Joost
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687033/
https://ncbi.nlm.nih.gov/pubmed/26689559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145397
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