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Chromothripsis and kataegis induced by telomere crisis
Telomere crisis occurs during tumorigenesis when depletion of the telomere reserve leads to frequent telomere fusions. The resulting dicentric chromosomes have been proposed to drive genome instability. Here we examine the fate of dicentric human chromosomes in telomere crisis. We observed that dice...
में बचाया:
| में प्रकाशित: | Cell |
|---|---|
| मुख्य लेखकों: | , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2015
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4687025/ https://ncbi.nlm.nih.gov/pubmed/26687355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.11.054 |
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