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The Effects of Unbound Mycophenolic Acid (MPA) on Inosine Monophosphate Dehydrogenase (IMPDH) Inhibition in Pediatric Kidney Transplant Patients

BACKGROUND: Mycophenolic acid (MPA) is a key immunosuppressive drug that acts through inhibition of inosine monophosphate dehydrogenase (IMPDH). MPA is commonly measured as part of therapeutic drug monitoring as the total concentration in plasma. However, it has been postulated that the free (unboun...

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Bibliografiske detaljer
Udgivet i:Ther Drug Monit
Main Authors: Smits, Thomas A., Cox, Shareen, Fukuda, Tsuyoshi, Sherbotie, Joseph, Ward, Robert, Goebel, Jens, Vinks, Alexander A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687018/
https://ncbi.nlm.nih.gov/pubmed/24739663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0000000000000081
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