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The Effects of Unbound Mycophenolic Acid (MPA) on Inosine Monophosphate Dehydrogenase (IMPDH) Inhibition in Pediatric Kidney Transplant Patients

BACKGROUND: Mycophenolic acid (MPA) is a key immunosuppressive drug that acts through inhibition of inosine monophosphate dehydrogenase (IMPDH). MPA is commonly measured as part of therapeutic drug monitoring as the total concentration in plasma. However, it has been postulated that the free (unboun...

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Bibliographic Details
Published in:Ther Drug Monit
Main Authors: Smits, Thomas A., Cox, Shareen, Fukuda, Tsuyoshi, Sherbotie, Joseph, Ward, Robert, Goebel, Jens, Vinks, Alexander A.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687018/
https://ncbi.nlm.nih.gov/pubmed/24739663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FTD.0000000000000081
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