Insulin-like growth factor (IGF)-I obliterates the pregnancy-associated protection against mammary carcinogenesis in rats: evidence that IGF-I enhances cancer progression through estrogen receptor-α activation via the mitogen-activated protein kinase pathway

INTRODUCTION: Pregnancy protects against breast cancer development in humans and rats. Parous rats have persistently reduced circulating levels of growth hormone, which may affect the activity of the growth hormone/insulin-like growth factor (IGF)-I axis. We investigated the effects of IGF-I on pari...

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Udgivet i:Breast Cancer Res
Main Authors: Thordarson, Gudmundur, Slusher, Nicole, Leong, Harriet, Ochoa, Dafne, Rajkumar, Lakshmanaswamy, Guzman, Raphael, Nandi, Satyabrata, Talamantes, Frank
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2004
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC468665/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15217511/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/bcr812
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