Insulin-like growth factor (IGF)-I obliterates the pregnancy-associated protection against mammary carcinogenesis in rats: evidence that IGF-I enhances cancer progression through estrogen receptor-α activation via the mitogen-activated protein kinase pathway

INTRODUCTION: Pregnancy protects against breast cancer development in humans and rats. Parous rats have persistently reduced circulating levels of growth hormone, which may affect the activity of the growth hormone/insulin-like growth factor (IGF)-I axis. We investigated the effects of IGF-I on pari...

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Main Authors: Thordarson, Gudmundur, Slusher, Nicole, Leong, Harriet, Ochoa, Dafne, Rajkumar, Lakshmanaswamy, Guzman, Raphael, Nandi, Satyabrata, Talamantes, Frank
Format: Artigo
Language:Inglês
Published: BioMed Central 2004
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC468665/
https://ncbi.nlm.nih.gov/pubmed/15217511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr812
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