Insulin-like growth factor (IGF)-I obliterates the pregnancy-associated protection against mammary carcinogenesis in rats: evidence that IGF-I enhances cancer progression through estrogen receptor-α activation via the mitogen-activated protein kinase pathway

INTRODUCTION: Pregnancy protects against breast cancer development in humans and rats. Parous rats have persistently reduced circulating levels of growth hormone, which may affect the activity of the growth hormone/insulin-like growth factor (IGF)-I axis. We investigated the effects of IGF-I on pari...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Breast Cancer Res
Autori principali: Thordarson, Gudmundur, Slusher, Nicole, Leong, Harriet, Ochoa, Dafne, Rajkumar, Lakshmanaswamy, Guzman, Raphael, Nandi, Satyabrata, Talamantes, Frank
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2004
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC468665/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15217511/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/bcr812
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi