In Silico Discovery and In Vitro Validation of Catechol-Containing Sulfonohydrazide Compounds as Potent Inhibitors of the Diguanylate Cyclase PleD

Biofilm formation is responsible for increased antibiotic tolerance in pathogenic bacteria. Cyclic di-GMP (c-di-GMP) is a widely used second-messenger signal that plays a key role in bacterial biofilm formation. c-di-GMP is synthesized by diguanylate cyclases (DGCs), a conserved class of enzymes abs...

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Vydáno v:J Bacteriol
Hlavní autoři: Fernicola, Silvia, Paiardini, Alessandro, Giardina, Giorgio, Rampioni, Giordano, Leoni, Livia, Cutruzzolà, Francesca, Rinaldo, Serena
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Meeting Presentations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686196/
https://ncbi.nlm.nih.gov/pubmed/26416830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00742-15
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