In Silico Discovery and In Vitro Validation of Catechol-Containing Sulfonohydrazide Compounds as Potent Inhibitors of the Diguanylate Cyclase PleD

Biofilm formation is responsible for increased antibiotic tolerance in pathogenic bacteria. Cyclic di-GMP (c-di-GMP) is a widely used second-messenger signal that plays a key role in bacterial biofilm formation. c-di-GMP is synthesized by diguanylate cyclases (DGCs), a conserved class of enzymes abs...

Full description

Saved in:
Bibliographic Details
Published in:J Bacteriol
Main Authors: Fernicola, Silvia, Paiardini, Alessandro, Giardina, Giorgio, Rampioni, Giordano, Leoni, Livia, Cutruzzolà, Francesca, Rinaldo, Serena
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Meeting Presentations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686196/
https://ncbi.nlm.nih.gov/pubmed/26416830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00742-15
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items