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In Silico Discovery and In Vitro Validation of Catechol-Containing Sulfonohydrazide Compounds as Potent Inhibitors of the Diguanylate Cyclase PleD
Biofilm formation is responsible for increased antibiotic tolerance in pathogenic bacteria. Cyclic di-GMP (c-di-GMP) is a widely used second-messenger signal that plays a key role in bacterial biofilm formation. c-di-GMP is synthesized by diguanylate cyclases (DGCs), a conserved class of enzymes abs...
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出版年: | J Bacteriol |
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主要な著者: | , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
American Society for Microbiology
2015
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4686196/ https://ncbi.nlm.nih.gov/pubmed/26416830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00742-15 |
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