In Silico Discovery and In Vitro Validation of Catechol-Containing Sulfonohydrazide Compounds as Potent Inhibitors of the Diguanylate Cyclase PleD

Biofilm formation is responsible for increased antibiotic tolerance in pathogenic bacteria. Cyclic di-GMP (c-di-GMP) is a widely used second-messenger signal that plays a key role in bacterial biofilm formation. c-di-GMP is synthesized by diguanylate cyclases (DGCs), a conserved class of enzymes abs...

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Bibliografiske detaljer
Udgivet i:	J Bacteriol
Main Authors:	Fernicola, Silvia, Paiardini, Alessandro, Giardina, Giorgio, Rampioni, Giordano, Leoni, Livia, Cutruzzolà, Francesca, Rinaldo, Serena
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology 2015
Fag:	Meeting Presentations
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4686196/ https://ncbi.nlm.nih.gov/pubmed/26416830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00742-15
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In Silico Discovery and In Vitro Validation of Catechol-Containing Sulfonohydrazide Compounds as Potent Inhibitors of the Diguanylate Cyclase PleD

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