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A lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase

Lipasin/Angptl8 is a feeding-induced hepatokine that regulates triglyceride (TAG) metabolism; its therapeutical potential, mechanism of action, and relation to the lipoprotein lipase (LPL), however, remain elusive. We generated five monoclonal lipasin antibodies, among which one lowered the serum TA...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fu, Zhiyao, Abou-Samra, Abdul B., Zhang, Ren
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685196/
https://ncbi.nlm.nih.gov/pubmed/26687026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18502
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