Wild type microglia do not arrest pathology in mouse models of Rett syndrome

Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by mutations in the X chromosomal gene Methyl-CpG-binding Protein 2 (MECP2) (1). RTT treatment so far is symptomatic. Mecp2 disruption in mice phenocopies major features of the syndrome (2) that can be reversed upon re-expression of...

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Publicado no:Nature
Main Authors: Wang, Jieqi, Wegener, Jan Eike, Huang, Teng-Wei, Sripathy, Smitha, De Jesus-Cortes, Hector, Xu, Pin, Tran, Stephanie, Knobbe, Whitney, Leko, Vid, Britt, Jeremiah, Starwalt, Ruth, McDaniel, Latisha, Ward, Chris, Parra, Diana, Newcomb, Benjamin, Lao, Uyen, Flowers, David A., Cullen, Sean, Jorstad, Nikolas L, Yang, Yue, Glaskova, Lena, Vigneau, Sebastian, Kozlitina, Julia, Reichardt, Sybille D., Reichardt, Holger M., Gärtner, Jutta, Bartolomei, Marisa S., Fang, Min, Loeb, Keith, Keene, C. Dirk, Bernstein, Irwin, Goodell, Margaret, Brat, Daniel J., Huppke, Peter, Neul, Jeffrey, Bedalov, Antonio, Pieper, Andrew A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684952/
https://ncbi.nlm.nih.gov/pubmed/25993969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14444
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