mGlu2 Receptor Agonism, but Not Positive Allosteric Modulation, Elicits Rapid Tolerance towards Their Primary Efficacy on Sleep Measures in Rats

G-protein-coupled receptor (GPCR) agonists are known to induce both cellular adaptations resulting in tolerance to therapeutic effects and withdrawal symptoms upon treatment discontinuation. Glutamate neurotransmission is an integral part of sleep-wake mechanisms, which processes have translational...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Ahnaou, Abdallah, Lavreysen, Hilde, Tresadern, Gary, Cid, Jose M., Drinkenburg, Wilhelmus H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684355/
https://ncbi.nlm.nih.gov/pubmed/26658273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144017
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