Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma

BACKGROUND: Pancreatic acinar cell carcinoma (ACC) is a rare tumor entity with an unfavorable prognosis. Recent whole-exome sequencing identified p53 mutations in a subset of human ACC. Activation of the mammalian target of rapamycin (mTOR) pathway is associated with various pancreatic neoplasms. We...

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Vydáno v:Mol Cancer
Hlavní autoři: Kong, Bo, Cheng, Tao, Qian, Chengjia, Wu, Weiwei, Steiger, Katja, Cao, Jing, Schlitter, Anna Melissa, Regel, Ivonne, Raulefs, Susanne, Friess, Helmut, Erkan, Mert, Esposito, Irene, Kleeff, Jörg, Michalski, Christoph W.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683950/
https://ncbi.nlm.nih.gov/pubmed/26683340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0483-1
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