Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma

BACKGROUND: Pancreatic acinar cell carcinoma (ACC) is a rare tumor entity with an unfavorable prognosis. Recent whole-exome sequencing identified p53 mutations in a subset of human ACC. Activation of the mammalian target of rapamycin (mTOR) pathway is associated with various pancreatic neoplasms. We...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Mol Cancer
Main Authors: Kong, Bo, Cheng, Tao, Qian, Chengjia, Wu, Weiwei, Steiger, Katja, Cao, Jing, Schlitter, Anna Melissa, Regel, Ivonne, Raulefs, Susanne, Friess, Helmut, Erkan, Mert, Esposito, Irene, Kleeff, Jörg, Michalski, Christoph W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2015
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683950/
https://ncbi.nlm.nih.gov/pubmed/26683340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0483-1
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla