Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice

Chronic alcohol consumption induces hepatic oxidative stress resulting in production of highly reactive electrophilic α/β-unsaturated aldehydes that have the potential to modify proteins. A primary mechanism of reactive aldehyde detoxification by hepatocytes is through GSTA4-driven enzymatic conjuga...

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Vydáno v:Redox Biol
Hlavní autoři: Shearn, Colin T., Fritz, Kristofer S., Shearn, Alisabeth H., Saba, Laura M., Mercer, Kelly E., Engi, Bridgette, Galligan, James J., Zimniak, Piotr, Orlicky, David J., Ronis, Martin J., Petersen, Dennis R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683459/
https://ncbi.nlm.nih.gov/pubmed/26654979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.11.013
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