Histone deacetylase inhibitors prevent pulmonary endothelial hyperpermeability and acute lung injury by regulating heat shock protein 90 function

Transendothelial hyperpermeability caused by numerous agonists is dependent on heat shock protein 90 (Hsp90) and leads to endothelial barrier dysfunction (EBD). Inhibition of Hsp90 protects and restores transendothelial permeability. Hyperacetylation of Hsp90, as by inhibitors of histone deacetylase...

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Veröffentlicht in:Am J Physiol Lung Cell Mol Physiol
Hauptverfasser: Joshi, Atul D., Barabutis, Nektarios, Birmpas, Charalampos, Dimitropoulou, Christiana, Thangjam, Gagan, Cherian-Shaw, Mary, Dennison, John, Catravas, John D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683315/
https://ncbi.nlm.nih.gov/pubmed/26498249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00180.2015
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