Histone deacetylase inhibitors prevent pulmonary endothelial hyperpermeability and acute lung injury by regulating heat shock protein 90 function

Transendothelial hyperpermeability caused by numerous agonists is dependent on heat shock protein 90 (Hsp90) and leads to endothelial barrier dysfunction (EBD). Inhibition of Hsp90 protects and restores transendothelial permeability. Hyperacetylation of Hsp90, as by inhibitors of histone deacetylase...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Joshi, Atul D., Barabutis, Nektarios, Birmpas, Charalampos, Dimitropoulou, Christiana, Thangjam, Gagan, Cherian-Shaw, Mary, Dennison, John, Catravas, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683315/
https://ncbi.nlm.nih.gov/pubmed/26498249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00180.2015
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