Hsp90 inhibition suppresses NF-κB transcriptional activation via Sirt-2 in human lung microvascular endothelial cells

The ability of anti-heat shock protein 90 (Hsp90) drugs to attenuate NF-κB-mediated transcription is the major basis for their anti-inflammatory properties. While the molecular mechanisms underlying this effect are not clear, they appear to be distinct in human endothelial cells. We now show for the...

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Bibliographic Details
Published in:Am J Physiol Lung Cell Mol Physiol
Main Authors: Thangjam, Gagan S., Birmpas, Charalampos, Barabutis, Nektarios, Gregory, Betsy W., Clemens, Mary Ann, Newton, Joseph R., Fulton, David, Catravas, John D.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896096/
https://ncbi.nlm.nih.gov/pubmed/27036868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00054.2016
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