Novel Mechanism of Attenuation of LPS-Induced NF-κB Activation by the Heat Shock Protein 90 Inhibitor, 17-N-allylamino-17-demethoxygeldanamycin, in Human Lung Microvascular Endothelial Cells

Heat shock protein (hsp) 90 inhibition attenuates NF-κB activation and blocks inflammation. However, the precise mechanism of NF-κB regulation by hsp90 in the endothelium is not clear. We investigated the mechanisms of hsp90 inhibition by 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) on NF-κB ac...

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Detalhes bibliográficos
Main Authors: Thangjam, Gagan S., Dimitropoulou, Chistiana, Joshi, Atul D., Barabutis, Nektarios, Shaw, Mary C., Kovalenkov, Yevgeniy, Wallace, Chistopher M., Fulton, David J., Patel, Vijay, Catravas, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068943/
https://ncbi.nlm.nih.gov/pubmed/24303801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0214OC
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