Heat Shock Protein 90 Inhibitors Prevent LPS-Induced Endothelial Barrier Dysfunction by Disrupting RhoA Signaling

Permeability of the endothelial monolayer is increased when exposed to the bacterial endotoxin LPS. Our previous studies have shown that heat shock protein (Hsp) 90 inhibitors protect and restore LPS-mediated hyperpermeability in bovine pulmonary arterial endothelial cells. In this study, we assesse...

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Hlavní autoři: Joshi, Atul D., Dimitropoulou, Christiana, Thangjam, Gagan, Snead, Connie, Feldman, Sara, Barabutis, Nektarios, Fulton, David, Hou, Yali, Kumar, Sanjiv, Patel, Vijay, Gorshkov, Boris, Verin, Alexander D., Black, Stephen M., Catravas, John D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2014
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930930/
https://ncbi.nlm.nih.gov/pubmed/23972231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0496OC
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