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Wild‐type p53 enhances endothelial barrier function by mediating RAC1 signalling and RhoA inhibition

Inflammation is the major cause of endothelial barrier hyper‐permeability, associated with acute lung injury and acute respiratory distress syndrome. This study reports that p53 “orchestrates” the defence of vascular endothelium against LPS, by mediating the opposing actions of Rac1 and RhoA in pulm...

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Dades bibliogràfiques
Publicat a:J Cell Mol Med
Autors principals: Barabutis, Nektarios, Dimitropoulou, Christiana, Gregory, Betsy, Catravas, John D.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824363/
https://ncbi.nlm.nih.gov/pubmed/29363851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13460
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