The T210M Substitution in the HLA-a*02:01 gp100 Epitope Strongly Affects Overall Proteasomal Cleavage Site Usage and Antigen Processing

MHC class I-restricted epitopes, which carry a tumor-specific mutation resulting in improved MHC binding affinity, are preferred T cell receptor targets in innovative adoptive T cell therapies. However, T cell therapy requires efficient generation of the selected epitope. How such mutations may affe...

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Pubblicato in:J Biol Chem
Autori principali: Textoris-Taube, Kathrin, Keller, Christin, Liepe, Juliane, Henklein, Petra, Sidney, John, Sette, Alessandro, Kloetzel, Peter M., Mishto, Michele
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683264/
https://ncbi.nlm.nih.gov/pubmed/26507656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.695189
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