Alzheimer's disease‐causing proline substitutions lead to presenilin 1 aggregation and malfunction

Do different neurodegenerative maladies emanate from the failure of a mutual protein folding mechanism? We have addressed this question by comparing mutational patterns that are linked to the manifestation of distinct neurodegenerative disorders and identified similar neurodegeneration‐linked prolin...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Ben‐Gedalya, Tziona, Moll, Lorna, Bejerano‐Sagie, Michal, Frere, Samuel, Cabral, Wayne A, Friedmann‐Morvinski, Dinorah, Slutsky, Inna, Burstyn‐Cohen, Tal, Marini, Joan C, Cohen, Ehud
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682640/
https://ncbi.nlm.nih.gov/pubmed/26438723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592042
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