A two-layered machine learning method to identify protein O-GlcNAcylation sites with O-GlcNAc transferase substrate motifs

Protein O-GlcNAcylation, involving the β-attachment of single N-acetylglucosamine (GlcNAc) to the hydroxyl group of serine or threonine residues, is an O-linked glycosylation catalyzed by O-GlcNAc transferase (OGT). Molecular level investigation of the basis for OGT's substrate specificity shou...

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Bibliographic Details
Published in:BMC Bioinformatics
Main Authors: Kao, Hui-Ju, Huang, Chien-Hsun, Bretaña, Neil Arvin, Lu, Cheng-Tsung, Huang, Kai-Yao, Weng, Shun-Long, Lee, Tzong-Yi
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682369/
https://ncbi.nlm.nih.gov/pubmed/26680539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-16-S18-S10
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