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Viral and Cellular Genomes Activate Distinct DNA Damage Responses
In response to cellular genome breaks, MRE11/RAD50/NBS1 (MRN) activates a global ATM DNA damage response (DDR) that prevents cellular replication. Here we show that MRN-ATM also has critical functions in defending the cell against DNA viruses. We reveal temporally distinct responses to adenovirus ge...
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| Publicado en: | Cell |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4681434/ https://ncbi.nlm.nih.gov/pubmed/26317467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.058 |
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