Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action

HIV-1 gp120 undergoes multiple conformational changes both before and after binding to the host CD4 receptor. BMS-626529 is an attachment inhibitor (AI) in clinical development (administered as prodrug BMS-663068) that binds to HIV-1 gp120. To investigate the mechanism of action of this new class of...

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發表在:Proteins
Main Authors: Langley, David R, Roy Kimura, S, Sivaprakasam, Prasanna, Zhou, Nannan, Dicker, Ira, McAuliffe, Brian, Wang, Tao, Kadow, John F, Meanwell, Nicholas A, Krystal, Mark
格式: Artigo
語言:Inglês
出版: Blackwell Publishing Ltd 2015
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681349/
https://ncbi.nlm.nih.gov/pubmed/25401969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24726
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