In Vitro Antiviral Characteristics of HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068

BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells. The activity of BMS-626529 is virus dependent, due to heterogeneity within gp120. In order to better understand the anti-HIV-1...

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Detalhes bibliográficos
Main Authors: Nowicka-Sans, Beata, Gong, Yi-Fei, McAuliffe, Brian, Dicker, Ira, Ho, Hsu-Tso, Zhou, Nannan, Eggers, Betsy, Lin, Pin-Fang, Ray, Neelanjana, Wind-Rotolo, Megan, Zhu, Li, Majumdar, Antara, Stock, David, Lataillade, Max, Hanna, George J., Matiskella, John D., Ueda, Yasutsugu, Wang, Tao, Kadow, John F., Meanwell, Nicholas A., Krystal, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393465/
https://ncbi.nlm.nih.gov/pubmed/22547625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00426-12
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