Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways

Dectin-1 is a C-type lectin receptor critical in anti-fungal immunity but Dectin-1 has not been linked to regulation of sterile inflammation or oncogenesis. We found that Dectin-1 expression is upregulated in hepatic fibrosis and liver cancer. However, Dectin-1 deletion exacerbates liver fibro-infla...

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Publicado en:Cell Rep
Autores principales: Seifert, Lena, Deutsch, Michael, Alothman, Sara, Alqunaibit, Dalia, Werba, Gregor, Pansari, Mridul, Pergamo, Matthew, Ochi, Atsuo, Torres-Hernandez, Alejandro, Levie, Elliot, Tippens, Daniel, Greco, Stephanie H., Tiwari, Shaun, Ly, Nancy Ngoc Giao, Eisenthal, Andrew, van Heerden, Eliza, Avanzi, Antonina, Barilla, Rocky, Zambirinis, Constantinos P., Rendon, Mauricio, Daley, Donnele, Pachter, H. Leon, Hajdu, Cristina, Miller, George
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681001/
https://ncbi.nlm.nih.gov/pubmed/26655905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.058
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