Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways

Dectin-1 is a C-type lectin receptor critical in anti-fungal immunity but Dectin-1 has not been linked to regulation of sterile inflammation or oncogenesis. We found that Dectin-1 expression is upregulated in hepatic fibrosis and liver cancer. However, Dectin-1 deletion exacerbates liver fibro-infla...

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Publicat a:Cell Rep
Autors principals: Seifert, Lena, Deutsch, Michael, Alothman, Sara, Alqunaibit, Dalia, Werba, Gregor, Pansari, Mridul, Pergamo, Matthew, Ochi, Atsuo, Torres-Hernandez, Alejandro, Levie, Elliot, Tippens, Daniel, Greco, Stephanie H., Tiwari, Shaun, Ly, Nancy Ngoc Giao, Eisenthal, Andrew, van Heerden, Eliza, Avanzi, Antonina, Barilla, Rocky, Zambirinis, Constantinos P., Rendon, Mauricio, Daley, Donnele, Pachter, H. Leon, Hajdu, Cristina, Miller, George
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681001/
https://ncbi.nlm.nih.gov/pubmed/26655905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.10.058
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