Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice

OBJECTIVE: Lynch syndrome is caused by germline mutations in DNA mismatch repair genes leading to microsatellite instability (MSI) and colorectal cancer. Mesalazine, commonly used for the treatment of UC, reduces MSI in vitro. Here, we tested natural compounds for such activity and applied mesalazin...

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Veröffentlicht in:Gut
Hauptverfasser: Kortüm, Benedikt, Campregher, Christoph, Lang, Michaela, Khare, Vineeta, Pinter, Matthias, Evstatiev, Rayko, Schmid, Gerald, Mittlböck, Martina, Scharl, Theresa, Kucherlapati, Melanie H, Edelmann, Winfried, Gasche, Christoph
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2015
Schlagworte:
GI cancer
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4680183/
https://ncbi.nlm.nih.gov/pubmed/25429050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-307663
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