Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice

OBJECTIVE: Lynch syndrome is caused by germline mutations in DNA mismatch repair genes leading to microsatellite instability (MSI) and colorectal cancer. Mesalazine, commonly used for the treatment of UC, reduces MSI in vitro. Here, we tested natural compounds for such activity and applied mesalazin...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Kortüm, Benedikt, Campregher, Christoph, Lang, Michaela, Khare, Vineeta, Pinter, Matthias, Evstatiev, Rayko, Schmid, Gerald, Mittlböck, Martina, Scharl, Theresa, Kucherlapati, Melanie H, Edelmann, Winfried, Gasche, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2015
Assuntos:
GI cancer
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4680183/
https://ncbi.nlm.nih.gov/pubmed/25429050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-307663
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