Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice

OBJECTIVE: Lynch syndrome is caused by germline mutations in DNA mismatch repair genes leading to microsatellite instability (MSI) and colorectal cancer. Mesalazine, commonly used for the treatment of UC, reduces MSI in vitro. Here, we tested natural compounds for such activity and applied mesalazin...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Gut
Autori principali: Kortüm, Benedikt, Campregher, Christoph, Lang, Michaela, Khare, Vineeta, Pinter, Matthias, Evstatiev, Rayko, Schmid, Gerald, Mittlböck, Martina, Scharl, Theresa, Kucherlapati, Melanie H, Edelmann, Winfried, Gasche, Christoph
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2015
Soggetti:
GI cancer
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4680183/
https://ncbi.nlm.nih.gov/pubmed/25429050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-307663
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi