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Mechanism of Thermal Adaptation in the Lactate Dehydrogenases

The mechanism of thermal adaptation of enzyme function at the molecular level is poorly understood but is thought to lie within the structure of the protein or its dynamics. Our previous work on pig heart lactate dehydrogenase (phLDH) has determined very high resolution structures of the active site...

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Bibliographic Details
Published in:J Phys Chem B
Main Authors: Peng, Huo-Lei, Egawa, Tsuyoshi, Chang, Eric, Deng, Hua, Callender, Robert
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679558/
https://ncbi.nlm.nih.gov/pubmed/26556099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.5b09909
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