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Mechanism of Thermal Adaptation in the Lactate Dehydrogenases

The mechanism of thermal adaptation of enzyme function at the molecular level is poorly understood but is thought to lie within the structure of the protein or its dynamics. Our previous work on pig heart lactate dehydrogenase (phLDH) has determined very high resolution structures of the active site...

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: Peng, Huo-Lei, Egawa, Tsuyoshi, Chang, Eric, Deng, Hua, Callender, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679558/
https://ncbi.nlm.nih.gov/pubmed/26556099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.5b09909
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