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Overexpression of Amyloid- β Protein Precursor Induces Mitochondrial Oxidative Stress and Activates the Intrinsic Apoptotic Cascade
Alzheimer's disease (AD) is a debilitating cognitive disorder which is characterized pathologically by amyloid-β plaques and neurofibrillary tangles. Aberrant processing of amyloid beta protein precursor (AβPP) into amyloid-β fragments underlies the formation of senile plaques. Moreover, amyloi...
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| Publicat a: | J Alzheimers Dis |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4679200/ https://ncbi.nlm.nih.gov/pubmed/22133762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-111172 |
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