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CK2 acts as a potent negative regulator of receptor-mediated insulin release in vitro and in vivo

G protein-coupled receptors (GPCRs) regulate virtually all physiological functions including the release of insulin from pancreatic β-cells. β-Cell M(3) muscarinic receptors (M3Rs) are known to play an essential role in facilitating insulin release and maintaining proper whole-body glucose homeostas...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rossi, Mario, Ruiz de Azua, Inigo, Barella, Luiz F., Sakamoto, Wataru, Zhu, Lu, Cui, Yinghong, Lu, Huiyan, Rebholz, Heike, Matschinsky, Franz M., Doliba, Nicolai M., Butcher, Adrian J., Tobin, Andrew B., Wess, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679045/
https://ncbi.nlm.nih.gov/pubmed/26598688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519430112
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