Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors

BACKGROUND: Adoptive cell transfer of tumor-specific T lymphocytes (T cells) is proving to be an effective strategy for treating established tumors in cancer patients. One method of generating these cells is accomplished through engineering bulk T cell populations to express chimeric antigen recepto...

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Pubblicato in:J Immunother Cancer
Autori principali: Hammill, Joanne A., VanSeggelen, Heather, Helsen, Christopher W., Denisova, Galina F., Evelegh, Carole, Tantalo, Daniela G. M., Bassett, Jennifer D., Bramson, Jonathan L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678647/
https://ncbi.nlm.nih.gov/pubmed/26673402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-015-0099-4
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