A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation

A comprehensive genome-wide screen of radiosensitization targets in HeLa cells was performed using a shRNA-library/functional cluster analysis and DNMT3B was identified as a candidate target. DNMT3B RNAi increased the sensitivity of HeLa, A549 and HCT116 cells to both γ-irradiation and carbon-ion be...

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Pubblicato in:Sci Rep
Autori principali: Fujimori, Hiroaki, Sato, Akira, Kikuhara, Sota, Wang, Junhui, Hirai, Takahisa, Sasaki, Yuka, Murakami, Yasufumi, Okayasu, Ryuichi, Masutani, Mitsuko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678329/
https://ncbi.nlm.nih.gov/pubmed/26667181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18231
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