Administration of Panobinostat Is Associated with Increased IL-17A mRNA in the Intestinal Epithelium of HIV-1 Patients

Intestinal CD4(+) T cell depletion is rapid and profound during early HIV-1 infection. This leads to a compromised mucosal barrier that prompts chronic systemic inflammation. The preferential loss of intestinal T helper 17 (Th17) cells in HIV-1 disease is a driver of the damage within the mucosal ba...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Mediators Inflamm
Autori principali: Bjerg Christensen, Ane, Dige, Anders, Vad-Nielsen, Johan, Brinkmann, Christel R., Bendix, Mia, Østergaard, Lars, Tolstrup, Martin, Søgaard, Ole S., Rasmussen, Thomas A., Randel Nyengaard, Jens, Agnholt, Jørgen, Denton, Paul W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2015
Soggetti:
Clinical Study
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678094/
https://ncbi.nlm.nih.gov/pubmed/26696749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/120605
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