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Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes

NAD(P)H-dependent enzymes are ubiquitous in metabolism and cellular processes and are also of great interest for pharmaceutical and industrial applications. Here, we present a structure-guided enzyme engineering strategy for improving catalytic properties of NAD(P)H-dependent enzymes toward native o...

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Detalhes bibliográficos
Publicado no:Protein Eng Des Sel
Main Authors: Cahn, J.K.B., Baumschlager, A., Brinkmann-Chen, S., Arnold, F.H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678007/
https://ncbi.nlm.nih.gov/pubmed/26512129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzv057
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