R-loops regulate promoter-proximal chromatin architecture and cellular differentiation

Numerous chromatin-remodeling factors are regulated by interactions with RNA, although the contexts and functions of RNA binding are poorly understood. Here we show that R-loops, RNA:DNA hybrids consisting of nascent transcripts hybridized to template DNA, modulate the binding of two key chromatin r...

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Bibliografiska uppgifter
I publikationen:Nat Struct Mol Biol
Huvudupphovsmän: Chen, Poshen B., Chen, Hsiuyi V., Acharya, Diwash, Rando, Oliver J., Fazzio, Thomas G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677832/
https://ncbi.nlm.nih.gov/pubmed/26551076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3122
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