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Effects of site-specific infusions of methionine sulfoximine on the temporal progression of seizures in a rat model of mesial temporal lobe epilepsy

Glutamine synthetase (GS) in astrocytes is critical for metabolism of glutamate and ammonia in the brain, and perturbations in the anatomical distribution and activity of the enzyme are likely to adversely affect synaptic transmission. GS is deficient in discrete regions of the hippocampal formation...

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Bibliografski detalji
Izdano u:Epilepsy Res
Glavni autori: Dhaher, Roni, Wang, Helen, Gruenbaum, Shaun E, Tu, Nathan, Lee, Tih-Shih W, Zaveri, Hitten P, Eid, Tore
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677790/
https://ncbi.nlm.nih.gov/pubmed/26220375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eplepsyres.2015.05.005
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